Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective.

ABSTRACT: The multifunctional antitumor properties of Withaferin A (WA), the manifold studied bioactive compound of the plant Withania somnifera, have been well established in many different in vitro and in vivo cancer models. This undoubtedly has led to a much better insight in the underlying mechanisms of WAs broad antitumor activity range, but also raises additional challenging questions on how all these antitumor properties could be explained on a molecular level. Therefore, a lot of effort was made to characterize the cellular WA target proteins, since these binding events will lead and initiate the observed downstream effects. Based on a proteomic perspective, this review provides novel insights in the molecular chain of events by which WA potentially exercises its antitum

SUBMITTER: Dom M 

PROVIDER: S-EPMC7523023 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature