The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection.

ABSTRACT:

Background

Tick-borne encephalitis virus (TBEV) is considered to be the medically most important arthropod-borne virus in Europe. The symptoms of an infection range from subclinical to mild flu-like disease to lethal encephalitis. The exact determinants of disease severity are not known; however, the virulence of the strain as well as the immune status of the host are thought to be important factors for the outcome of the infection. Here we investigated virulence determinants in TBEV infection.

Method

Mice were infected with different TBEV strains, and high virulent and low virulent TBEV strains were chosen. Sequence alignment identified differences that were cloned to generate chimera virus. The infection rate of the parental and chimeric virus were evaluated in primary mou

SUBMITTER: Lindqvist R 

PROVIDER: S-EPMC7523050 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature