Non-randomised evaluations of strategies to increase participant retention in randomised controlled trials: a systematic review.

ABSTRACT:

Background

Retention of participants is essential to ensure the statistical power and internal validity of clinical trials. Poor participant retention reduces power and can bias the estimates of intervention effect. There is sparse evidence from randomised comparisons of effective strategies to retain participants in randomised trials. Currently, non-randomised evaluations of trial retention interventions embedded in host clinical trials are rejected from the Cochrane review of strategies to improve retention because it only included randomised evaluations. However, the systematic assessment of non-randomised evaluations may inform trialists' decision-making about retention methods that have been evaluated in a trial context.Therefore, we performed a systematic review to synthesise

SUBMITTER: Elfeky A 

PROVIDER: S-EPMC7523052 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature