Circulating Tumor DNA as a Prognostic Biomarker in Localized Non-small Cell Lung Cancer.

ABSTRACT:

Background

Routine clinical surveillance involves serial radiographic imaging following radical surgery in localized non-small cell lung cancer (NSCLC). However, such surveillance can detect only macroscopic disease recurrence and is frequently inconclusive. We investigated if detection of ctDNA before and after resection of NSCLC identifies the patients with risk of relapse, and furthermore, informs about response to management.

Methods

We recruited a total of 77 NSCLC patients. A high-throughput 127 target-gene capture technology and a high-sensitivity circulating single-molecule amplification and resequencing technology (cSMART) assay were used to detect the somatic mutations in the tumor tissues as well as the plasma of NSCLC patients before and after surgery to monitor

SUBMITTER: Peng M 

PROVIDER: S-EPMC7523087 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature