Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma.

ABSTRACT:

Background

Cabozantinib inhibits tyrosine kinases, including vascular endothelial growth factor receptors 1, 2, and 3, MET, and AXL, which are implicated in the progression of hepatocellular carcinoma and the development of resistance to sorafenib, the standard initial treatment for advanced disease. This randomized, double-blind, phase 3 trial evaluated cabozantinib as compared with placebo in previously treated patients with advanced hepatocellular carcinoma.

Methods

A total of 707 patients were randomly assigned in a 2:1 ratio to receive cabozantinib (60 mg once daily) or matching placebo. Eligible patients had received previous treatment with sorafenib, had disease progression after at least one systemic treatment for hepatocellular carcinoma, and may have received up to

SUBMITTER: Abou-Alfa GK 

PROVIDER: S-EPMC7523244 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature