Physiological effects of adding ECCO₂R to invasive mechanical ventilation for COPD exacerbations.

ABSTRACT:

Background

Extracorporeal CO₂ removal (ECCO₂R) could be a valuable additional modality for invasive mechanical ventilation (IMV) in COPD patients suffering from severe acute exacerbation (AE). We aimed to evaluate in such patients the effects of a low-to-middle extracorporeal blood flow device on both gas exchanges and dynamic hyperinflation, as well as on work of breathing (WOB) during the IMV weaning process.

Study design and methods

Open prospective interventional study in 12 deeply sedated IMV AE-COPD patients studied before and after ECCO₂R initiation. Gas exchange and dynamic hyperinflation were compared after stabilization without and with ECCO₂R (Hemolung, Alung, Pittsburgh, USA) combined with a specific adjustment algorith

SUBMITTER: Diehl JL 

PROVIDER: S-EPMC7523267 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature