Combination of plasma amyloid beta_(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology.

ABSTRACT:

Background

Blood-based biomarkers for Alzheimer's disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma markers Abeta_(1-42/1-40), glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) to identify cerebral amyloidosis and/or disease severity.

Methods

We included individuals with a positive (n = 176: 63 ± 7 years, 87 (49%) females) or negative (n = 76: 61 ± 9 years, 27 (36%) females) amyloid PET status, with syndrome diagnosis subjective cognitive decline (18 PET+, 25 PET-), mild cognitive impairment (26 PET+, 24 PET-), or AD-dementia (132 PET+). Plasma Abeta_(1-42/1-40), GFAP, and NfL were measured by Simoa.

SUBMITTER: Verberk IMW 

PROVIDER: S-EPMC7523295 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature