Mammographic density change in a cohort of premenopausal women receiving tamoxifen for breast cancer prevention over 5 years.

ABSTRACT:

Background

A decrease in breast density due to tamoxifen preventive therapy might indicate greater benefit from the drug. It is not known whether mammographic density continues to decline after 1 year of therapy, or whether measures of breast density change are sufficiently stable for personalised recommendations.

Methods

Mammographic density was measured annually over up to 5 years in premenopausal women with no previous diagnosis of breast cancer but at increased risk of breast cancer attending a family-history clinic in Manchester, UK (baseline 2010-2013). Tamoxifen (20 mg/day) for prevention was prescribed for up to 5 years in one group; the other group did not receive tamoxifen and were matched by age. Fully automatic methods were used on mammograms over the 5-year foll

SUBMITTER: Brentnall AR 

PROVIDER: S-EPMC7523310 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature