Accelerated long-term forgetting in healthy older adults predicts cognitive decline over 1 year.

ABSTRACT:

Background

Here, we address a pivotal factor in Alzheimer's prevention-identifying those at risk early, when dementia can still be avoided. Recent research highlights an accelerated forgetting phenotype as a risk factor for Alzheimer's disease. We hypothesized that delayed recall over 4 weeks would predict cognitive decline over 1 year better than 30-min delayed recall, the current gold standard for detecting episodic memory problems which could be an early clinical manifestation of incipient Alzheimer's disease. We also expected hippocampal subfield volumes to improve predictive accuracy.

Methods

Forty-six cognitively healthy older people (mean age 70.7 ± 7.97, 21/46 female), recruited from databases such as Join Dementia Research, or a local database of volunteers, perform

SUBMITTER: Wearn AR 

PROVIDER: S-EPMC7523317 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature