Individual neuronal subtypes control initial myelin sheath growth and stabilization.

ABSTRACT:

Background

In the developing central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process extensions. Some contacts stabilize, leading to the initiation of axon wrapping, nascent myelin sheath formation, concentric wrapping and sheath elongation, and sheath stabilization or pruning by oligodendrocytes. Although axonal signals influence the overall process of myelination, the precise oligodendrocyte behaviors that require signaling from axons are not completely understood. In this study, we investigated whether oligodendrocyte behaviors during the early events of myelination are mediated by an oligodendrocyte-intrinsic myelination program or are over-ridden by axonal factors.

Methods

To address this, we utilized in

SUBMITTER: Nelson HN 

PROVIDER: S-EPMC7523326 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature