Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.

ABSTRACT: Oxidative stress is a central part of innate immune-induced neurodegeneration. However, the transcriptomic landscape of central nervous system (CNS) innate immune cells contributing to oxidative stress is unknown, and therapies to target their neurotoxic functions are not widely available. Here, we provide the oxidative stress innate immune cell atlas in neuroinflammatory disease and report the discovery of new druggable pathways. Transcriptional profiling of oxidative stress-producing CNS innate immune cells identified a core oxidative stress gene signature coupled to coagulation and glutathione-pathway genes shared between a microglia cluster and infiltrating macrophages. Tox-seq followed by a microglia high-throughput screen and oxidative stress gene network analysis identified the glut

SUBMITTER: Mendiola AS 

PROVIDER: S-EPMC7523413 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature