Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients.

ABSTRACT:

Background

Systemic infiltration of the brain by tumor cells is a hallmark of glioma pathogenesis which may cause disturbances in functional connectivity. We hypothesized that aggressive high-grade tumors cause more damage to functional connectivity than low-grade tumors.

Methods

We designed an imaging tool based on resting-state functional (f)MRI to individually quantify abnormality of functional connectivity and tested it in a prospective cohort of patients with newly diagnosed glioma.

Results

Thirty-four patients were analyzed (World Health Organization [WHO] grade II, n = 13; grade III, n = 6; grade IV, n = 15; mean age, 48.7 y). Connectivity abnormality could be observed not only in the lesioned brain area but also in the contralateral hemisphere with a close cor

SUBMITTER: Stoecklein VM 

PROVIDER: S-EPMC7523460 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature