Comparison of Antihypertensive Drug Classes for Dementia Prevention.

ABSTRACT:

Background

Hypertension in midlife is associated with increased risk of Alzheimer disease and vascular dementia late in life. In addition, some antihypertensive drugs have been proposed to have cognitive benefits, independent of their effect on hypertension. Consequently, there is potential to repurpose antihypertensive drugs for the prevention of dementia. This study systematically compared seven antihypertensive drug classes for this purpose, using the Clinical Practice Research Datalink.

Methods

We assessed treatments for hypertension in an instrumental variable analysis to address potential confounding and reverse causation. We used physicians' prescribing preference as an ordinal instrument, defined by the physicians' last seven prescriptions. Participants considered we

SUBMITTER: Walker VM 

PROVIDER: S-EPMC7523578 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature