Integrating ab initio and template-based algorithms for protein-protein complex structure prediction.

ABSTRACT:

Motivation

Template-based and template-free methods have both been widely used in predicting the structures of protein-protein complexes. Template-based modeling is effective when a reliable template is available, while template-free methods are required for predicting the binding modes or interfaces that have not been previously observed. Our goal is to combine the two methods to improve computational protein-protein complex structure prediction.

Results

Here, we present a method to identify and combine high-confidence predictions of a template-based method (SPRING) with a template-free method (ZDOCK). Cross-validated using the protein-protein docking benchmark version 5.0, our method (ZING) achieved a success rate of 68.2%, outperforming SPRING and ZDOCK, with success rate

SUBMITTER: Vangaveti S 

PROVIDER: S-EPMC7523679 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature