A Higher Fluid Balance in the Days After Septic Shock Reversal Is Associated With Increased Mortality: An Observational Cohort Study.

ABSTRACT:

Objectives

Previous studies demonstrated that extensive fluid loading and consequently positive fluid balances during sepsis resuscitation are associated with adverse outcome. Yet, the association between fluid balance and mortality after reversal of shock, that is, during deresuscitation, is largely unappreciated. Our objective was to investigate the effects of fluid balance on mortality in the days after septic shock reversal.

Design

Retrospective observational cohort study.

Setting

ICUs of two university-affiliated hospitals in The Netherlands.

Patients

Adult patients admitted with septic shock followed by shock reversal. Reversal of septic shock was defined based on Sepsis-3 criteria as the first day that serum lactate was less than or equal to 2 mmol/L wit

SUBMITTER: van Mourik N 

PROVIDER: S-EPMC7523767 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature