Multimarker approach including CRP, sST2 and GDF-15 for prognostic stratification in stable heart failure.

ABSTRACT:

Aims

Inflammation and cardiac remodelling are common and synergistic pathways in heart failure (HF). Emerging biomarkers such as soluble suppression of tumorigenicity 2 (sST2) and growth differentiation factor-15 (GDF-15), which are linked to inflammation and fibrosis process, have been proposed as prognosis factors. However, their potential additive values remain poorly investigated.

Methods and results

Here, we aimed at evaluating inflammatory and remodelling biomarkers to predict both short-term and long-term mortality in a population with chronic HF in comparison with other classical clinical or biological markers (i.e. N terminal pro brain natriuretic peptide, hs-cTnT, C-reactive protein) alone or using meta-analysis global group in chronic HF risk score in a cohort of

SUBMITTER: Kuster N 

PROVIDER: S-EPMC7524044 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature