Prolonged suppression of the anti-oxidant/anti-inflammatory effects of BNP post-Takotsubo syndrome.

ABSTRACT:

Aims

Takotsubo syndrome (TTS) episodes are primarily initiated by 'pulse' release of catecholamines inducing neutrophil infiltration and myocardial inflammation in susceptible individuals (largely ageing women). Evidence of myocardial inflammation and associated energetic impairment persists for ≥ 3 months post-acute TTS episodes, suggesting the existence of additional 'perpetuating' mechanisms. The effects of B-type natriuretic peptide (BNP) in suppressing superoxide (O₂ ^- ) release from neutrophils are transiently impaired in acute heart failure. We also evaluated the extent and duration of BNP-induced suppression of O₂ ^- release post-TTS.

Methods and results

TTS patients were studied acutely (n = 34) and 3 months thereafter (n =

SUBMITTER: Liu S 

PROVIDER: S-EPMC7524045 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature