Effect of melatonin on heart failure: design for a double-blinded randomized clinical trial.

ABSTRACT:

Aims

Current studies indicate that melatonin can counteract renin-angiotensin-aldosterone system and sympathetic over activity in heart failure (HF) and might have a protective and repairing effect on cardiovascular injuries, skeletal muscle weakness, and metabolic abnormalities, which are common pathological processes in patients with HF. The MeHR trial (Melatonin for Heart Failure with Reduced Ejection Fraction) aims to evaluate the effect of oral melatonin on myocardial, skeletal muscle, and metabolic dysfunctions in HF, which leads to lower quality of life and increased morbidity and mortality in these patients.

Methods and results

This is a double-blind randomized clinical trial with two parallel arms of 1:1 allocation, which recruits 90 outpatients with HF with reduced

SUBMITTER: Sadeghi M 

PROVIDER: S-EPMC7524054 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature