ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction.

ABSTRACT:

Aims

The prevalence of heart failure with preserved ejection fraction (HFpEF) is still increasing, and so far, no pharmaceutical treatment has proven to be effective. A key obstacle for testing new pharmaceutical substances is the availability of suitable animal models for HFpEF, which realistically reflect the clinical picture. The aim of the present study was to characterize the development of HFpEF and skeletal muscle (SM) dysfunction in ZSF1 rats over time.

Methods and results

Echocardiography and functional analyses of the SM were performed in 6-, 10-, 15-, 20-, and 32-week-old ZSF1-lean and ZSF1-obese. Furthermore, myocardial and SM tissue was collected for molecular and histological analyses. HFpEF markers were evident as early as 10 weeks of age. Diastolic dysfunctio

SUBMITTER: Schauer A 

PROVIDER: S-EPMC7524062 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature