Incremental prognostic value of a novel metabolite-based biomarker score in congestive heart failure patients.

ABSTRACT:

Aims

The Cardiac Lipid Panel (CLP) is a newly discovered panel of metabolite-based biomarkers that has shown to improve the diagnostic value of N terminal pro B type natriuretic peptide (NT-proBNP). However, little is known about its usefulness in predicting outcomes. In this study, we developed a risk score for 4-year cardiovascular death in elderly chronic heart failure (CHF) patients using the CLP.

Methods and results

From the Cardiac Insufficiency Bisoprolol Study in Elderly trial, we included 280 patients with CHF aged >65 years. A targeted metabolomic analysis of the CLP biomarkers was performed on baseline serum samples. Cox regression was used to determine the association of the biomarkers with the outcome after accounting for established risk factors. A risk score r

SUBMITTER: McGranaghan P 

PROVIDER: S-EPMC7524071 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature