Sequential nephron blockade with combined diuretics improves diastolic function in patients with resistant hypertension.

ABSTRACT:

Aims

Hypertension is a major contributor to cardiac diastolic dysfunction. Different therapeutics strategies have been proposed to control blood pressure (BP), but their independent impact on cardiac function remains undetermined. In patients with resistant hypertension, we compared the changes in cardiac parameters between two strategies based on sequential nephron blockade (NBD) with a combination of diuretics or sequential renin-angiotensin system blockade (RASB).

Methods and results

After a 4-week period where all patients received Irbesartan 300 mg/day + hydrochlorothiazide 12.5 mg/day + amlodipine 5 mg/day, 140 resistant hypertension patients (54.8 ± 11.1 years, 76% men, mean duration with hypertension: 13.1 ± 10.5 years, no previous history of heart failure or current

SUBMITTER: Fouassier D 

PROVIDER: S-EPMC7524081 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature