Elevated plasma phenylalanine predicts mortality in critical patients with heart failure.

ABSTRACT:

Aims

Previous studies found a relationship between elevated phenylalanine levels and poor cardiovascular outcomes. Potential strategies are available to manipulate phenylalanine metabolism. This study investigated whether increased phenylalanine predicted mortality in critical patients with either acute heart failure (HF) or acute on chronic HF, and its correlation with inflammation and immune cytokines.

Methods and results

This study recruited 152 subjects, including 115 patients with HF admitted for critical conditions and 37 normal controls. We measured left ventricular ejection fraction (LVEF), plasma concentrations of phenylalanine, C-reactive protein, albumin, pre-albumin, transferrin, and pro-inflammatory and immune cytokines. Acute Physiology and Chronic Health Evalu

SUBMITTER: Chen WS 

PROVIDER: S-EPMC7524095 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature