Ethnic differences in association of outcomes with trimethylamine N-oxide in acute heart failure patients.

ABSTRACT:

Aims

The aim of this study was to investigate whether ethnicity influences the associations between trimethylamine N-oxide (TMAO) levels and heart failure (HF) outcomes.

Methods and results

Trimethylamine N-oxide levels were measured in two cohorts with acute HF at two sites. The UK Leicester cohort consisted mainly of Caucasian (n = 842, 77%) and South Asian (n = 129, 12%) patients, whereas patients in the Japanese cohort (n = 116, 11%) were all Japanese. The primary endpoint was the measurement of all-cause mortality and/or HF rehospitalization within 1 year post-admission. Association of TMAO levels with outcome was compared in the entire population and between ethnic groups after adjustment for clinical parameters. TMAO levels were significantly higher in Japanese patien

SUBMITTER: Yazaki Y 

PROVIDER: S-EPMC7524106 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature