Elevated N-terminal prohormone of brain natriuretic peptide among persons living with HIV in a South African peri-urban township.

ABSTRACT:

Aims

Efforts to improve access to antiretroviral therapy (ART) have shifted morbidity and mortality among persons living with HIV (PLWH) from AIDS to non-communicable diseases, such as cardiovascular disease (CVD). However, contemporary data on CVD among PLWH in sub-Saharan Africa in the current ART era are lacking. The aim of this study was to assess the burden of cardiac stress among PLWH in South Africa via measurement of N-terminal prohormone of brain natriuretic peptide (NT-proBNP).

Methods and results

NT-proBNP was measured at baseline in 224 PLWH enrolled in a sub-study of a tuberculosis vaccine trial in Khayelitsha township near Cape Town, South Africa. Thresholds were applied at the assay's limit of detection (≥137 pg/mL) and a level indicative of symptomatic heart

SUBMITTER: Peterson TE 

PROVIDER: S-EPMC7524119 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature