The importance of heart rate in isoprenaline-induced takotsubo-like cardiac dysfunction in rats.

ABSTRACT:

Aims

Takotsubo syndrome (TS) is an acute cardiac syndrome characterized by regional myocardial akinesia that cannot be attributed to a culprit lesion in coronary arteries. Cardiac overstimulation by catecholamines in the setting of stress is implicated in the pathogenesis of TS. While catecholamine-induced alterations in cardiac contractility have been studied as part of the causal pathway in TS, the importance of catecholamine-mediated tachycardia has not been studied. Our aim was to explore whether the reduction in heart rate, either by pharmacological suppression of the sinoatrial node with ivabradine or by surgical induction of third-degree atrioventricular block, prevents isoprenaline-induced TS-like akinesia in an experimental animal model.

Methods and results

We used

SUBMITTER: Ali A 

PROVIDER: S-EPMC7524126 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature