Coagulation factor XIII activity predicts left ventricular remodelling after acute myocardial infarction.

ABSTRACT:

Aims

Acute myocardial infarction (MI) is the major cause of chronic heart failure. The activity of blood coagulation factor XIII (FXIIIa) plays an important role in rodents as a healing factor after MI, whereas its role in healing and remodelling processes in humans remains unclear. We prospectively evaluated the relevance of FXIIIa after acute MI as a potential early prognostic marker for adequate healing.

Methods and results

This monocentric prospective cohort study investigated cardiac remodelling in patients with ST-elevation MI and followed them up for 1 year. Serum FXIIIa was serially assessed during the first 9 days after MI and after 2, 6, and 12 months. Cardiac magnetic resonance imaging was performed within 4 days after MI (Scan 1), after 7 to 9 days (Scan 2), and

SUBMITTER: Frey A 

PROVIDER: S-EPMC7524135 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature