Ontology highlight
ABSTRACT:
SUBMITTER: Foulke-Abel J
PROVIDER: S-EPMC7524150 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Foulke-Abel Jennifer J Yu Huimin H Sunuwar Laxmi L Lin Ruxian R Fleckenstein James M JM Kaper James B JB Donowitz Mark M
Gut microbes 20200507 1
Diarrhea caused by enterotoxigenic <i>Escherichia coli</i> (ETEC) has a continuing impact on residents and travelers in underdeveloped countries. Both heat-labile (LT) and heat-stable (ST) enterotoxins contribute to pathophysiology via induction of cyclic nucleotide synthesis, and previous investigations focused on intracellular signal transduction rather than possible intercellular second messenger signaling. We modeled ETEC infection in human jejunal enteroid/organoid monolayers (HEM) and eval ...[more]