Peptidase PepP is a novel virulence factor of <i>Campylobacter jejuni</i> contributing to murine campylobacteriosis.

ABSTRACT: Mechanisms of host-pathogen interactions resulting in immunopathological responses upon human Campylobacter jejuni infection are not completely understood, but the recent availability of murine infection models mimicking key features of campylobacteriosis helps solving this dilemma. During a screen for proteases expressed by C. jejuni, we identified a peptidase of the M24 family as a potential novel virulence factor, which was named PepP. The gene is strongly conserved in various Campylobacter species. A constructed deletion mutant ΔpepP of C. jejuni strain 81-176 grew as efficiently compared to isogenic wild-type (WT) or pepP complemented bacteria. To shed light on the potential role of this protease in mediating immunopathological responses in th

SUBMITTER: Heimesaat MM 

PROVIDER: S-EPMC7524167 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature