DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure.

ABSTRACT:

Aims

Natriuretic peptides are useful for diagnosis and prognostication of heart failure of any cause. Now, research aims to discover novel biomarkers that will more specifically define the heart failure phenotype. DNA methylation plays a critical role in the development of cardiovascular disease with the potential to predict fundamental pathogenic processes. There is a lack of data relating DNA methylation in heart failure that specifically focuses on patients with severe multi-vessel coronary artery disease. To begin to address this, we conducted a pilot study uniquely exploring the utility of powerful whole-genome methyl-binding domain-capture sequencing in a cohort of cardiac surgery patients, matched for the severity of their coronary artery disease, aiming to identify candidat

SUBMITTER: Bain CR 

PROVIDER: S-EPMC7524212 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature