Prognostic impact of mineralocorticoid receptor antagonist in patients with heart failure with preserved ejection fraction.

ABSTRACT:

Aims

This study aims to investigate the prognostic impact of mineralocorticoid receptor antagonists (MRAs) on cardiovascular events in patients hospitalized for acute decompensated heart failure with preserved ejection fraction (HFpEF; defined as left ventricular ejection fraction ≥45%).

Methods and results

A prospective multicentre cohort study was conducted in Nagano prefecture, Japan, between July 2014 and December 2018 that contained 518 consecutive HFpEF patients hospitalized for acute decompensated heart failure (HF). The primary outcome was a composite of cardiovascular death and HF readmission. We compared the incidence of cardiovascular events between patients who were prescribed with MRAs and those who were not in a propensity score matched cohort using a Cox propo

SUBMITTER: Suzuki S 

PROVIDER: S-EPMC7524222 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature