Extracellular vesicle Cystatin C and CD14 are associated with both renal dysfunction and heart failure.

ABSTRACT:

Aims

Extracellular vesicles (EVs) are small double-membrane plasma vesicles that play key roles in cellular crosstalk and mechanisms such as inflammation. The role of EVs in combined organ failure such as cardiorenal syndrome has not been investigated. The aim of this study is to identify EV proteins that are associated with renal dysfunction, heart failure, and their combination in dyspnoeic patients.

Methods and results

Blood samples were prospectively collected in 404 patients presenting with breathlessness at the emergency department at National University Hospital, Singapore. Renal dysfunction was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m² . The presence of heart failure was independently adjudicated by two clinicians on the basis of

SUBMITTER: Verbree-Willemsen L 

PROVIDER: S-EPMC7524227 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature