Prognostic impact of additional mineralocorticoid receptor antagonists in octogenarian heart failure patients.

ABSTRACT:

Aims

Guideline-directed medical therapy (GDMT) including beta-blockers and renin-angiotensin system inhibitors is shown to reduce mortality risk in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). However, there is little evidence about the efficacy of additional administration of mineralocorticoid receptor antagonists (MRAs) with GDMT in patients ≥80 years presenting with HF. We aimed to investigate the prognostic impact of GDMT with MRA in relation to the age of patients with HF.

Methods and results

This observational study included patients admitted for HF with reduced LVEF who were discharged alive; among them, 224 patients were ≥80 years, and 661 patients were <80 years. Both populations were divided into three groups depending on

SUBMITTER: Abe T 

PROVIDER: S-EPMC7524245 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature