Clinical characteristics and natural history of wild-type transthyretin amyloid cardiomyopathy in Japan.

ABSTRACT:

Aims

The focus on wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is increasing because of novel treatment options. There is currently no report on a large number of Japanese patients with ATTRwt-CM. The study aimed to examine the characteristics and prognosis of ATTRwt-CM in Japan.

Methods and results

Consecutive patients (78.5 ± 6.4 years old at diagnosis) with ATTRwt-CM diagnosed at Kumamoto University Hospital between December 2002 and December 2019 were retrospectively reviewed. Data, including demographic characteristics, co-morbidities, clinical manifestations at diagnosis, laboratory results, electrocardiographic and echocardiographic data, imaging and pathological findings, and treatment were obtained. Of 129 patients included in this study, 110 patients

SUBMITTER: Yamada T 

PROVIDER: S-EPMC7524255 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature