Gut microbiota derived metabolites contribute to intestinal barrier maturation at the suckling-to-weaning transition.

ABSTRACT: In suckling mammals, the onset of solid food ingestion is coincident with the maturation of the gut barrier. This ontogenic process is driven by the colonization of the intestine by the microbiota. However, the mechanisms underlying the microbial regulation of the intestinal development in early life are not fully understood. Here, we studied the co-maturation of the microbiota (composition and metabolic activity) and of the gut barrier at the suckling-to-weaning transition by using a combination of experiments in vivo (suckling rabbit model), ex vivo (Ussing chambers) and in vitro (epithelial cell lines and organoids). The microbiota composition, its metabolic activity, para-cellular epithelial permeability and the gene expression of key components of the gut barrier

SUBMITTER: Beaumont M 

PROVIDER: S-EPMC7524271 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature