The development of metabolic endotoxemia is dependent on the type of sweetener and the presence of saturated fat in the diet.

ABSTRACT: Fat and sweeteners contribute to obesity. However, it is unknown whether specific bacteria are selectively modified by different caloric and noncaloric sweeteners with or without a high-fat diet (HFD). Here, we combined extensive host phenotyping and shotgun metagenomics of the gut microbiota to investigate this question. We found that the type of sweetener and its combination with an HFD selectively modified the gut microbiota. Sucralose and steviol glycosides led to the lowest α-diversity of the gut microbiota. Sucralose increased the abundance of B. fragilis in particular, resulting in a decrease in the abundance of occludin and an increase in proinflammatory cytokines, glucose intolerance, fatty acid oxidation and ketone bodies. Sucrose+HFD showed the highest metabolic endotoxem

SUBMITTER: Sanchez-Tapia M 

PROVIDER: S-EPMC7524302 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature