Cancer-protective effect of a synbiotic combination between <i>Lactobacillus gasseri</i> 505 and a <i>Cudrania tricuspidata</i> leaf extract on colitis-associated colorectal cancer.

ABSTRACT: Previously, a synbiotic combination of probiotic Lactobacillus gasseri 505 (LG) and a new prebiotic, Cudrania tricuspidata leaf extract (CT) in fermented milk, designated FCT, showed an in vitro immunomodulatory effect and antioxidant activity. Although synbiotic combination might have cancer-protective effects, these activities have not been fully validated in vivo. Ten-week treatment of LG, CT, or FCT to azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colitis-associated colorectal cancer (CAC) mouse model reduced both the incidence of colonic tumors and damage to the colonic mucosa effectively, suggesting a cancer-protective effect. To understand these, biomarkers associated with inflammation, colon barrier, apoptosis, and cancer cell proliferation wer

SUBMITTER: Oh NS 

PROVIDER: S-EPMC7524312 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature