Environmental and intrinsic factors shaping gut microbiota composition and diversity and its relation to metabolic health in children and early adolescents: A population-based study.

ABSTRACT:

Background

Gut microbiota, by influencing multiple metabolic processes in the host, is an important determinant of human health and disease. However, gut dysbiosis associated with metabolic complications shows inconsistent patterns. This is likely driven by factors shaping gut microbial composition that have largely been under-evaluated, at a population level, in school-age children, especially from developing countries.

Results

Through characterization, by 16S sequencing, of the largest gut microbial population-based school-aged children cohort in Latin America (ORSMEC, N = 926, aged 6-12 y), we identified associations of 14 clinical and environmental covariates (P_FDR<0.1), collectively explaining 15.7% of the inter-individual gut microbial variation. Extr

SUBMITTER: Moran-Ramos S 

PROVIDER: S-EPMC7524342 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature