Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health.

ABSTRACT: Bile acid metabolism by the gut microbiome exerts both beneficial and harmful effects on host health. Microbial bile salt hydrolases (BSHs), which initiate bile acid metabolism, exhibit both positive and negative effects on host physiology. In this study, 5,790 BSH homologs were collected and classified into seven clusters based on a sequence similarity network. Next, the abundance and distribution of BSH in 380 metagenomes from healthy participants were analyzed. It was observed that different clusters occupied diverse ecological niches in the human microbiome and that the clusters with signal peptides were relatively abundant in the gut. Then, the association between BSH clusters and 12 human diseases was analyzed by comparing the abundances of BSH genes in patients (n = 1,605) an

SUBMITTER: Jia B 

PROVIDER: S-EPMC7524343 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature