Beneficial bacteria activate type-I interferon production via the intracellular cytosolic sensors STING and MAVS.

ABSTRACT: Type-I interferon (IFN-I) cytokines are produced by immune cells in response to microbial infections, cancer and autoimmune diseases, and subsequently, trigger cytoprotective and antiviral responses through the activation of IFN-I stimulated genes (ISGs). The ability of intestinal microbiota to modulate innate immune responses is well known, but the mechanisms underlying such responses remain elusive. Here we report that the intracellular sensors stimulator of IFN genes (STING) and mitochondrial antiviral signaling (MAVS) are essential for the production of IFN-I in response to lactic acid bacteria (LAB), common gut commensal bacteria with beneficial properties. Using human macrophage cells we show that LAB strains that potently activate the inflammatory transcription factor NF-κB are poor

SUBMITTER: Gutierrez-Merino J 

PROVIDER: S-EPMC7524384 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature