Maternal sucralose intake alters gut microbiota of offspring and exacerbates hepatic steatosis in adulthood.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is considered to be associated with diet and gut dysbiosis. Excessive sucralose can induce gut dysbiosis and negatively affect host health. Maternal diet shapes the microbial communities of neonate and this effect continues in later life. We aimed to investigate the effects of maternal sucralose (MS) intake on the susceptibility of offspring to hepatic steatosis in adulthood.

Methods

C57BL/6 pregnant mice were randomized into MS group (MS during gestation and lactation) and maternal control (MC) group (MC diet). After weaning, all offspring were fed a control diet until 8 weeks of age, and then treated with a high-fat diet (HFD) for 4 weeks. The intestinal development, mucosal barrier function, and gut microbiota were asses

SUBMITTER: Dai X 

PROVIDER: S-EPMC7524393 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature