N-acetylcysteine as an adjunctive treatment for smoking cessation: a randomized clinical trial.

ABSTRACT:

Objective

This randomized controlled trial examined the efficacy and safety of N-acetylcysteine as an adjunctive treatment for smoking cessation.

Methods

Heavy smokers were recruited from smoking cessation treatment for this 12- week randomized controlled trial. Eligible tobacco use disorder outpatients (n=34) were randomized to N-acetylcysteine or placebo plus first-line treatment. Abstinence was verified by exhaled carbon monoxide (COexh). The assessment scales included the Fagerström Test for Nicotine Dependence, the Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, the Minnesota Nicotine Withdrawal Scale, and the Medication Adherence Rating Scale. We also assessed anthropometrics, blood pressure, lipid profile, and soluble tumor necrosis factor recepto

SUBMITTER: Machado RCBR 

PROVIDER: S-EPMC7524413 | biostudies-literature | 2020 Sep-Oct

REPOSITORIES: biostudies-literature