SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany.

ABSTRACT:

Objectives

Investigation whether in depth characterization of virus variant patterns can be used for epidemiological analysis of the first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection clusters in Hamburg, Germany.

Methods

Metagenomic RNA-sequencing and amplicon-sequencing and subsequent variant calling in 25 respiratory samples from SARS-CoV-2 infected patients involved in the earliest infection clusters in Hamburg.

Results

Amplikon sequencing and cluster analyses of these SARS-CoV-2 sequences allowed the identification of the first infection cluster and five non-related infection clusters occurring at the beginning of the viral entry of SARS-CoV-2 in the Hamburg metropolitan region. Viral genomics together with epidemiological analyses revea

SUBMITTER: Pfefferle S 

PROVIDER: S-EPMC7524521 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature