Low-to-moderate dose corticosteroids treatment in hospitalized adults with COVID-19.

ABSTRACT:

Objectives

Use of corticosteroids is common in the treatment of coronavirus disease 2019, but clinical effectiveness is controversial. We aimed to investigate the association of corticosteroids therapy with clinical outcomes of hospitalized COVID-19 patients.

Methods

In this single-centre, retrospective cohort study, adult patients with confirmed coronavirus disease 2019 and dead or discharged between 29 December 2019 and 15 February 2020 were studied; 1:1 propensity score matchings were performed between patients with or without corticosteroid treatment. A multivariable COX proportional hazards model was used to estimate the association between corticosteroid treatment and in-hospital mortality by taking corticosteroids as a time-varying covariate.

Results

Among 646

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7524527 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature