Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex.

ABSTRACT: In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum. Although electrical synapses can entrain activity within neuronal assemblies, their role in feed-forward circuits is less well explored. By combining whole-cell patch-clamp and 2-photon laser scanning microscopy of basket cells (BCs), we found that classical excitatory postsynaptic currents (EPSCs) are followed by GABAA receptor-independent outward currents, reflecting the hyperpolarization component of spikelets (a synapse-evoked action potential passively propagating from electrically coupled neighbors). FF recruitment of the spikelet-mediated inhibition curtails the integration time window of concomitant excitatory postsynap

SUBMITTER: Hoehne A 

PROVIDER: S-EPMC7524550 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature