Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity.

ABSTRACT: Alzheimer's disease is the most common neurodegenerative disorder. Finding a pharmacological approach that cures and/or prevents the onset of this devastating disease represents an important challenge for researchers. According to the amyloid cascade hypothesis, increases in extracellular amyloid-β (Aβ) levels give rise to different aggregated species, such as protofibrils, fibrils and oligomers, with oligomers being the more toxic species for cells. Many efforts have recently been focused on multi-target ligands to address the multiple events that occur concurrently with toxic aggregation at the onset of the disease. Moreover, investigating the effect of endogenous compounds or a combination thereof is a promising approach to prevent the side effects of entirely synthetic drugs. In this w

SUBMITTER: Greco V 

PROVIDER: S-EPMC7524733 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature