Enhanced LTP of population spikes in the dentate gyrus of mice haploinsufficient for neurobeachin.

ABSTRACT: Deletion of the autism candidate molecule neurobeachin (Nbea), a large PH-BEACH-domain containing neuronal protein, has been shown to affect synaptic function by interfering with neurotransmitter receptor targeting and dendritic spine formation. Previous analysis of mice lacking one allele of the Nbea gene identified impaired spatial learning and memory in addition to altered autism-related behaviours. However, no functional data from living heterozygous Nbea mice (Nbea^+/-) are available to corroborate the behavioural phenotype. Here, we explored the consequences of Nbea haploinsufficiency on excitation/inhibition balance and synaptic plasticity in the intact hippocampal dentate gyrus of Nbea^+/- animals in vivo by electrophysiological recordings. Based on field potent

SUBMITTER: Muellerleile J 

PROVIDER: S-EPMC7524738 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature