H₂O₂ and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum.

ABSTRACT: Although a physiological role for redox signaling is now clearly established, the processes sensitive to redox signaling remains to be identified. Ratiometric probes selective for H₂O₂ have revealed its complex spatiotemporal dynamics during neural development and adult regeneration and perturbations of H₂O₂ levels disturb cell plasticity and morphogenesis. Here we ask whether endogenous H₂O₂ could participate in the patterning of the embryo. We find that perturbations of endogenous H₂O₂ levels impact on the distribution of the Engrailed homeoprotein, a strong determinant of midbrain patterning. Engrailed 2 is secreted from cells with high H₂O₂ levels and taken up by cells with low

SUBMITTER: Amblard I 

PROVIDER: S-EPMC7524761 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature