Precision multidimensional neural population code recovered from single intracellular recordings.

ABSTRACT: Neurons in sensory cortices are more naturally and deeply integrated than any current neural population recording tools (e.g. electrode arrays, fluorescence imaging). Two concepts facilitate efforts to observe population neural code with single-cell recordings. First, even the highest quality single-cell recording studies find a fraction of the stimulus information in high-dimensional population recordings. Finding any of this missing information provides proof of principle. Second, neurons and neural populations are understood as coupled nonlinear differential equations. Therefore, fitted ordinary differential equations provide a basis for single-trial single-cell stimulus decoding. We obtained intracellular recordings of fluctuating transmembrane current and potential in mouse visual cor

SUBMITTER: Johnson JK 

PROVIDER: S-EPMC7524839 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature