Impact of Helminth Infection on Metabolic and Immune Homeostasis in Non-diabetic Obesity.

ABSTRACT: Several epidemiological and immunological studies indicate a reciprocal association between obesity/metabolic syndrome and helminth infections. Numerous studies demonstrated that obesity is concomitant with chronic low-grade inflammation, which is marked by vital changes in cellular composition and function of adipose tissue. However, the effect of helminth infection on the homeostatic milieu in obesity is not well-understood. To determine the relationship between Strongyloides stercoralis (Ss) infection and obesity, we examined an array of parameters linked with obesity both before and at 6 months following anthelmintic treatment. To this end, we measured serum levels of pancreatic hormones, incretins, adipokines and Type-1, Type-2, Type-17, and other proinflammatory cytokines in t

SUBMITTER: Rajamanickam A 

PROVIDER: S-EPMC7524873 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature