Limonene-induced activation of A_2A adenosine receptors reduces airway inflammation and reactivity in a mouse model of asthma.

ABSTRACT: Animal models of asthma have shown that limonene, a naturally occurring terpene in citrus fruits, can reduce inflammation and airway reactivity. However, the mechanism of these effects is unknown. We first performed computational and molecular docking analyses that showed limonene could bind to both A_2A and A_2B receptors. The pharmacological studies were carried out with A_2A adenosine receptor knock-out (A_2AKO) and wild-type (WT) mice using ovalbumin (OVA) to generate the asthma phenotype. We investigated the effects of limonene on lung inflammation and airway responsiveness to methacholine (MCh) and NECA (nonselective adenosine analog) by administering limonene as an inhalation prior to OVA aerosol challenges in one group of allergic mice for bo

SUBMITTER: Patel M 

PROVIDER: S-EPMC7524888 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature